Since the horrific events destroyed by the villains like Electro, Green Goblin, RHINO or Human Torch, Spider-Man and SHIELD forces have stopped and arrested them, returning peace to the New York City. Not long after that, the life of the people here is once again turned upside down by another character, who owns the Venom suit. After a while of trying to chase, Spider-Man got the suit, but the owner of that escaped and left bad consequences when rescuing the whole villains once captured by SHIELD. Everywhere, criminals are causing trouble, even kidnapping innocent people. Spider-Man must find the tycoon who standing behind these incidents while trying to stop those criminals doing bad things.
